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6-Trifluoromethyl-3-pyridinesulfonyl Chloride is a chemical used for the preparation of N-sulfonamido polycyclic pyrazolyl compounds for treatment of cognitive disorders.
Richard J. Cremlyn,; Graham P. Jones,; Fred J. Swinbourne,; Kin Yung.Some Reactions Of Pyridine-3-Sulfonyl Chloride. Phosphorus and Sulfur and the Related Elements. 1980, 8(2), 189-195.
Danielle L. Aubele,; Anh P. Truong,; Darren B. Dressen,; Gary D. Probst,; Simeon Bowers,; Matthew N. Mattson,; Chris M. Semko,; Minghua Sun,; Albert W. Garofalo,; Andrei W. Konradi,; Hing L. Sham,; Wes Zmolek,; Karina Wong,; Erich Goldbach,; Kevin P. Quinn,; John-Michael Sauer.Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors . Bioorganic & Medicinal Chemistry Letters. 2011, 21(19), 5791-5794.
Hazard Statements: H314-H335
Causes severe skin burns and eye damage. May cause respiratory irritation.
Precautionary Statements: P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant