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6893-02-3 - 3,3',5-Triiodo-L-thyronine, 95% - O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine - Liothyronine - H34068 - Alfa Aesar

H34068 3,3',5-Triiodo-L-thyronine, 95%

CAS Number
6893-02-3
Synonyms
O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine
Liothyronine

Size Price ($) Quantity Availability
250mg 58.86
1g 187.46
5g 565.20
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3,3',5-Triiodo-L-thyronine, 95%

MDL
MFCD00002593
EINECS
229-999-3

Chemical Properties

Formula
C15H12I3NO4
Formula Weight
650.97
Melting point
234-238°
Sensitivity
Light Sensitive
Solubility
Insoluble in water, ethanol and propylene glycol. Soluble in dilute alkalies.

Applications

Using video intensification fluorescence microscopy and tetramethylrhodamine (Rho)-labeled 3, 3', 5-triiodo-L-thyronine (T3),the uptake of T3 by cultured mouse fibroblasts was studied. The binding of 3, 3', 5-triiodo-L-thyronine (T3) to GH3 rat pituitary tumor cells was studied at 15 degrees C and was shown to be saturable, reversible, and stereospecific. A fluorescent derivative of the thyroid hormone 3,3'-triiodo-L-thyronine binds to cultured mouse fibroblasts; such binding is saturable. 3,3?,5-Triiodo-L-thyronine Up-regulation of Na,K-ATPase Activity and Cell Surface Expression in Alveolar Epithelial Cells Is Src Kinase- and Phosphoinositide 3-Kinase-dependent.

Notes

Light Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, Strong bases, light.

Literature References

R Horiuchi,; M L Johnson,; M C Willingham,; I Pastan,; S Cheng. Affinity labeling of the plasma membrane 3,3',5-triiodo-L-thyronine receptor in GH3 cells. PNAS. 1982 , 79(18),5527-5531.

Jianxun Lei,; Cary N. Mariash.; David H. Ingbar. 3,3?,5-Triiodo-L-thyronine Up-regulation of Na,K-ATPase Activity and Cell Surface Expression in Alveolar Epithelial Cells Is Src Kinase- and Phosphoinositide 3-Kinase-dependent . Journal of Biological Chemistry. 2004 , 279 , 47589-47600..

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2937.90
TSCA
No
RTECS
AY6750000

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