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H34309 4,5,6,7-Tetrahydrobenzo[b]thiophene, 97%

CAS Number

Stock No. Size Price ($) Quantity Availability
H34309-MD 250mg 50.90
H34309-03 1g 140.00
H34309-06 5g 469.00
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4,5,6,7-Tetrahydrobenzo[b]thiophene, 97%


Chemical Properties

Formula Weight
Boiling Point
Refractive Index
Storage & Sensitivity
Air Sensitive. Store under Argon. Ambient temperatures.


It is an active pharmaceutical intermediate. Condensation of amino carboxyalkyl derivative of 4,5,6,7-tetrahydrobenzo[b]thiophene with salicylaldehyde yielded a potentially tridentate Schiff base (HSAT), which formed a series of copper(II) complexes. Reaction of ethyl 2-diazo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 1 with 3-iminobutyronitrile 2 gave the hydrazone derivative.


Air sensitive. Store at room temperature. Keep container tightly closed in a dry and well-ventilated place.

Literature References

V. Alagarsamy.;S. Meena.; K.V. Ramseshu.; V.R. Solomon.; K. Thirumurugan.; K. Dhanabal.; M. Murugan. Synthesis, analgesic, anti-inflammatory, ulcerogenic index and antibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-4(3H)-ones. Eur. J. Med. Chem. 2006, 41 (11),1293-1300.

Rafat M. Mohareb,; Fatma M. Manhi. Reaction of ethyl 2-diazo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate with 3-iminobutyronitrile: synthesis of pyridazines, thiophenes, and their fused derivatives. Heteroatom Chemistry. 2000, 11 (6), 403-412,.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

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