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H34396 4-Trifluoromethyl-1H-pyrazole, 97%

CAS Number
52222-73-8
Synonyms

Stock No. Size Price ($) Quantity Availability
H34396-MD 250mg 176.00
H34396-03 1g 580.00
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4-Trifluoromethyl-1H-pyrazole, 97%

MDL
MFCD11226572

Chemical Properties

Formula
C4H3F3N2
Formula Weight
136.10
Melting point
76-78°
Storage & Sensitivity
Ambient temperatures.

Applications

It is used as pharmaceutical intermediates. The palladium-catalyzed cross-coupling reactions of 5-tributylstannyl-4-fluoro-1H-pyrazole with aryl iodides provided high yields of the corresponding 5-aryl-4-fluoro-1H-pyrazoles.

Notes

Incompatible with strong oxidizing agents. Store at room temperature.

Literature References

Takeshi Hanamotoa.; Takao Suetake.; Yukinori Koga.; Toshio Kawanami.; Hiroshi Furuno.; Junji Inanag. Synthesis and reactions of 5-tributylstannyl-4-fluoro-1H-pyrazole.Tetrahedron. 2007, 63 (23), 5062-5070.

Rukkiat Jitchati.; Andrei S. Batsanov.; Martin R. Bryce. N-Arylation of nitrogen heterocycles with 2,4-difluoroiodobenzene. Tetrahedron. 2009, 65 (4), 855-861.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2933.19
TSCA
No

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