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52222-73-8 - 4-Trifluoromethyl-1H-pyrazole, 97% - H34396 - Alfa Aesar

H34396 4-Trifluoromethyl-1H-pyrazole, 97%

CAS Number

Size Price ($) Quantity Availability
250mg 173.60
1g 622.12
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4-Trifluoromethyl-1H-pyrazole, 97%


Chemical Properties

Formula Weight
Melting point


It is used as pharmaceutical intermediates. The palladium-catalyzed cross-coupling reactions of 5-tributylstannyl-4-fluoro-1H-pyrazole with aryl iodides provided high yields of the corresponding 5-aryl-4-fluoro-1H-pyrazoles.


Incompatible with strong oxidizing agents. Store at room temperature.

Literature References

Takeshi Hanamotoa.; Takao Suetake.; Yukinori Koga.; Toshio Kawanami.; Hiroshi Furuno.; Junji Inanag. Synthesis and reactions of 5-tributylstannyl-4-fluoro-1H-pyrazole.Tetrahedron. 2007, 63 (23), 5062-5070.

Rukkiat Jitchati.; Andrei S. Batsanov.; Martin R. Bryce. N-Arylation of nitrogen heterocycles with 2,4-difluoroiodobenzene. Tetrahedron. 2009, 65 (4), 855-861.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code


  • H54504

    2-(4-Nitrophenyl)ethanol, 98%
  • A14056

    2-Vinylpyridine, 97%, stab. with 0.1% 4-tert-butylcatechol
  • H33778

    4-Fluoro-3-methyl(thiobenzamide), 97%
  • L02371

    Diethyl benzamidomalonate, 98+%
  • 16801

    Tri-n-hexyl phosphate, 90+%

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