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It is used in the design, synthesis and biological evaluation of novel condensed fuoropyrimidines as anti-hyperlipidemic agents. Synthesis of 2-chloromethyl-5-(4- chlorophenyl) thieno [2,3-d]pyrimidin- 4(3H)-one. A stream of dry hydrogen chloride gas was bubbled through an ice-cold mixture of ethyl 2-amino-4-(4-chlorophenyl)thiophene 3- carboxylate.
Henning Lütjens.; Andrea Zickgraf .; Heidi Figler.; Joel Linden.; Ray A. Olsson.; Peter J. Scammells. 2-Amino-3-benzoylthiophene Allosteric Enhancers of A1 Adenosine Agonist Binding:? New 3, 4-, and 5-Modifications. J. Med. Chem. 2003, 46 (10),1870-1877.
Kamaraj Balamurugan.; Subbu Perumal.; Aaramadaka Sunil Kumar Reddy.; Perumal Yogeeswari.; Dharmarajan Sriram. A facile domino protocol for the regioselective synthesis and discovery of novel 2-amino-5-arylthieno-[2,3-b]thiophenes as antimycobacterial agents.Tetrahedron Lett. 2009, 50 (45),6191-6195.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant