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65234-09-5 - Ethyl 2-amino-4-(4-chlorophenyl)thiophene-3-carboxylate, 96% - 2-Amino-4-(4-chlorophenyl)thiophene-3-carboxylic acid ethyl ester - H34427 - Alfa Aesar

H34427 Ethyl 2-amino-4-(4-chlorophenyl)thiophene-3-carboxylate, 96%

CAS Number
2-Amino-4-(4-chlorophenyl)thiophene-3-carboxylic acid ethyl ester

Size Price ($) Quantity Availability
1g 35.40
10g 228.66
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Ethyl 2-amino-4-(4-chlorophenyl)thiophene-3-carboxylate, 96%


Chemical Properties

Formula Weight
Melting point


It is used in the design, synthesis and biological evaluation of novel condensed fuoropyrimidines as anti-hyperlipidemic agents. Synthesis of 2-chloromethyl-5-(4- chlorophenyl) thieno [2,3-d]pyrimidin- 4(3H)-one. A stream of dry hydrogen chloride gas was bubbled through an ice-cold mixture of ethyl 2-amino-4-(4-chlorophenyl)thiophene 3- carboxylate.


Incompatible with strong oxidizing agents. Store at room temperature.

Literature References

Henning Lütjens.; Andrea Zickgraf .; Heidi Figler.; Joel Linden.; Ray A. Olsson.; Peter J. Scammells. 2-Amino-3-benzoylthiophene Allosteric Enhancers of A1 Adenosine Agonist Binding:? New 3, 4-, and 5-Modifications. J. Med. Chem. 2003, 46 (10),1870-1877.

Kamaraj Balamurugan.; Subbu Perumal.; Aaramadaka Sunil Kumar Reddy.; Perumal Yogeeswari.; Dharmarajan Sriram. A facile domino protocol for the regioselective synthesis and discovery of novel 2-amino-5-arylthieno-[2,3-b]thiophenes as antimycobacterial agents.Tetrahedron Lett. 2009, 50 (45),6191-6195.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

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