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H35148 N-Methoxycarbonyl-L-tert-leucine, 98%

CAS Number
162537-11-3
Synonyms
N-Moc-L-tert-leucine

Stock No. Size Price ($) Quantity Availability
H35148-03 1g 39.30
H35148-06 5g 155.00
H35148-14 25g 624.00
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N-Methoxycarbonyl-L-tert-leucine, 98%

MDL
MFCD07778455

Chemical Properties

Formula
C8H15NO4
Formula Weight
189.21
Melting point
107-110°
Storage & Sensitivity
Keep Cold.
Solubility
Soluble in ethyl acetate and methanol.

Applications

The coupling of the two key intermediates, N-(methoxycarbonyl)-l-tert-leucine acylated benzyl hydrazine and chloromethyl ketone, via an S N 2 reaction furnished the amino ketone in high yield under our optimized conditions in practical synthesis of the HIV Protease Inhibitor Atazanavir via a Highly diastereoselective Reduction Approach.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, heat.

Literature References

Xing Fan,; Yan-Li Song,; Ya-Qiu Long. An Efficient and Practical Synthesis of the HIV Protease Inhibitor Atazanavir via a Highly Diastereoselective Reduction Approach. Org. Process Res. Dev.,2008 , 12/span>(1),69-75.

Zhongmin Xu,; Janak Singh,; Mark D. Schwinden,; Bin Zheng,; Thomas P. Kissic,; Bharat Patel,; Michael J. Humora,; Fernando Quiroz,; Lin Dong,;‡ Dau-Ming Hsieh. Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632. Org. Proc. Res. Dev.2002, 6(3) ,323-328.

Other References

Harmonized Tariff Code
2922.49
TSCA
No

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