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It is used to prepare γ-aminophosphonates (N-arylamide phosphonates as subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. It is also used to synthesize N-sulfonylated propargylglycine derivatives as metalloproteinase inhibitors. Also widely utilized in the asymmetric synthesis of natural products.
Foss, F., et al. Synthesis and biological evaluation of γ-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorganic & Medicinal Chemistry. 2007, 15(2), 663-677.
Natchus, M., et al. Development of New Carboxylic Acid-Based MMP Inhibitors Derived from Functionalized Propargylglycines. J. Med. Chem. 2001, 44(7), 1060-1071.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.