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Isopropylmagnesium chloride is used in the regioselective functionalization of trisubstituted pyridines, electrophilic amination for preparation of amines and functionalization of cyclopentene derivatives. It is involved in the preparation of 2,3-functionalized furans, benzofurans, and thiophenes. Further, it is used in benzylic Grignards via sulfur-magnesium exchange.
Huddleston, N. E.; Roy, A.; Bilbrey, J. A.; Zhao, Y.; Locklin, J. Functionalization of Reactive End Groups in Surface-Initiated Kumada Catalyst-Transfer Polycondensation. Macromol. Symp. 2015, 351 (1), 27-36.
Hickey, M. J.; Kingston, L. P.; Allen, P. H.; Johnson, T.; Wilkinson, D. J. A short expedient synthesis of [14C]Ticlopidine. J. Labelled Compd. Radiopharm. 2014, 57 (3), 172-174.
Hazard Statements: H225-H261-H314-H318
Highly flammable liquid and vapour. In contact with water releases flammable gas. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P223-P210-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from any possible contact with water, because of violent reaction and possible flash fire. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.