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H51156 Isopropylmagnesium chloride - LiCl complex, 1M in MeTHF

CAS Number
807329-97-1
Synonyms

Stock No. Size Price ($) Quantity Availability
H51156-AE 100ml 254.00
H51156-AP 500ml 1015.00
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Isopropylmagnesium chloride - LiCl complex, 1M in MeTHF

MDL
MFCD07784514

Chemical Properties

Formula
C3H7ClMg.LiCl
Formula Weight
145.24
Flash Point
-17°(1.4°F)
Density
0.951
Storage & Sensitivity
Moisture Sensitive. Air Sensitive. Ambient temperatures.
Solubility
Miscible with ethers and amines.

Applications

Isopropylmagnesium chloride is used in the regioselective functionalization of trisubstituted pyridines, electrophilic amination for preparation of amines and functionalization of cyclopentene derivatives. It is involved in the preparation of 2,3-functionalized furans, benzofurans, and thiophenes. Further, it is used in benzylic Grignards via sulfur-magnesium exchange.

Notes

Air and moisture sensitive. Incompatible with oxidizing agents and water.

Literature References

Huddleston, N. E.; Roy, A.; Bilbrey, J. A.; Zhao, Y.; Locklin, J. Functionalization of Reactive End Groups in Surface-Initiated Kumada Catalyst-Transfer Polycondensation. Macromol. Symp. 2015, 351 (1), 27-36.

Hickey, M. J.; Kingston, L. P.; Allen, P. H.; Johnson, T.; Wilkinson, D. J. A short expedient synthesis of [14C]Ticlopidine. J. Labelled Compd. Radiopharm. 2014, 57 (3), 172-174.

GHS Hazard and Precautionary Statements

Hazard Statements: H225-H260-H302-H314-H335

Highly flammable liquid and vapour. In contact with water releases flammable gases which may ignite spontaneously. Harmful if swallowed. Causes severe skin burns and eye damage. May cause respiratory irritation.

Precautionary Statements: P210-P223-P231+P232-P233-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P335+P334-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep away from any possible contact with water, because of violent reaction and possible flash fire. Handle under inert gas. Protect from moisture. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Hazard Class
4.3
Packing Group
II
Harmonized Tariff Code
2931.90
TSCA
No

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