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4-Fluorophenylmagnesium bromide is used as a reagent for the introduction of the 4-Fluorophenyl group.
Namyong Y.Kim; Paul E.Laibinis. Derivatization of porous silicon by Grignard Reagents at room temperature. J. Am. Chem. Soc. 1998, 120, (18),4516-4517
K.S.Keshava Murthy; Allan W.Rey; Michael Tjepkema. Enantioselective synthesis of 3-substituted-4-aryl piperidines useful for the preparation of paroxetine. Tetrahedron Letters. 2003, 44, (28),5355-5358
Hazard Statements: H225-H261-H302-H314-H335
Highly flammable liquid and vapour. In contact with water releases flammable gas. Harmful if swallowed. Causes severe skin burns and eye damage. May cause respiratory irritation.
Precautionary Statements: P210-P223-P231+P232-P233-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P335+P334-P363-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep away from any possible contact with water, because of violent reaction and possible flash fire. Handle under inert gas. Protect from moisture. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant