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It can be heated to produce 2-trifluoromethyl-3H-quinazoline-4-thione in the presence of reagent molecular sieves and solvent CHCl3 with reaction time of 2 hours. It is an important organic intermediate used in agrochemicals, pharmaceuticals and dyestuff fields.
Chia-Yang Shiau, et al. Reactions of 2-aminothiobenzamide with isocyanates: a new synthesis of 2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one and 3,4-dihydro-2H-pyrimido[1,2-c]quinazolin-6(7H)-one. J. Heterocycl. Chem.,1989,26(3), 595-596.
R. Morrin Acheson, et al. Synthesis and X-ray crystal structures of 2,3-dihydro-2-mercapto-2,1,3-benzophosphadiazine-4(1H)-thione 2-sulphide derivatives.J. Chem. Soc., Perkin Trans. 2,1985,(12), 1913-1917.
Hazard Statements: H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P280h-P305+P351+P338
Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.