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51805-45-9 - Tris(2-carboxyethyl)phosphine hydrochloride, 95%, 0.5M soln. in water - TCEP HCl - H51864 - Alfa Aesar

H51864 Tris(2-carboxyethyl)phosphine hydrochloride, 95%, 0.5M soln. in water

CAS Number

Size Price ($) Quantity Availability
5ml 39.04
25ml 158.62
100ml 400.00
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Tris(2-carboxyethyl)phosphine hydrochloride, 95%, 0.5M soln. in water


Chemical Properties

Formula Weight
Miscible with water and methanol.


Tris(2-carboxyethyl)phosphine hydrochloride is widely used as a reducing agent to reduce disulfide bonds in proteins and trans-4,5-dihydroxy-1,2-dithiane. It is involved in the reduction of sulfoxides, sulfonyl chlorides, N-oxides and azides. It plays an important role in the tissue homogenization process for RNA isolation. It acts as a chelating agent and forms complexes with various heavy metal ions such as Zn(II), Cd(II), Pb(II), and Ni(II). Furthermore, it is useful in the labeling of cysteine residues with maleimides.


Air sensitive. Store in cool place. Incompatible with strong oxidizing agents

Literature References

La, M.; Feng, Y.; Yang, C.; Chen, C. Performances of p-Aminophenol Redox Cycling by Thiols and Tris (2-carboxyethyl) phosphine on Cysteamine-and 3-Mercaptopropionic acid-Covered Gold Electrodes. Int. J. Electrochem. Sci. 2014, 9, 6985-6992.

Miralles, G.; Verdie?, P.; Puget, K.; Maurras, A.; Martinez, J.; Subra, G. Microwave-mediated reduction of disulfide bridges with supported (Tris (2-carboxyethyl) phosphine) as resin-bound reducing agent. ACS Comb. Sci. 2013, 15 (4), 169-173.

GHS Hazard and Precautionary Statements

Hazard Statements: H314

Causes severe skin burns and eye damage.

Precautionary Statements: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
Packing Group
Harmonized Tariff Code


  • 36480

    Dimethyl sulfoxide, ACS, 99.9% min
  • A14730

    L-Arginine monohydrochloride, 98+%
  • 40587

    Tris(2-carboxyethyl)phosphine hydrochloride, 98%
  • A10713

    Ethylenediaminetetraacetic acid, 99%
  • A10761

    (1-Dodecyl)trimethylammonium bromide, 99%

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