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H51864 Tris(2-carboxyethyl)phosphine hydrochloride, 95%, 0.5M soln. in water

CAS Number
51805-45-9
Synonyms
TCEP HCl

Stock No. Size Price ($) Quantity Availability
H51864-AA 5ml 41.00
H51864-AC 25ml 167.00
H51864-AE 100ml 541.00
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Tris(2-carboxyethyl)phosphine hydrochloride, 95%, 0.5M soln. in water

MDL
MFCD00145469

Chemical Properties

Formula
C9H15O6P•HCl
Formula Weight
286.65
Storage & Sensitivity
Ambient temperatures.
Solubility
Miscible with water and methanol.

Applications

Tris(2-carboxyethyl)phosphine hydrochloride is widely used as a reducing agent to reduce disulfide bonds in proteins and trans-4,5-dihydroxy-1,2-dithiane. It is involved in the reduction of sulfoxides, sulfonyl chlorides, N-oxides and azides. It plays an important role in the tissue homogenization process for RNA isolation. It acts as a chelating agent and forms complexes with various heavy metal ions such as Zn(II), Cd(II), Pb(II), and Ni(II). Furthermore, it is useful in the labeling of cysteine residues with maleimides.

Notes

Air sensitive. Store in cool place. Incompatible with strong oxidizing agents

Literature References

La, M.; Feng, Y.; Yang, C.; Chen, C. Performances of p-Aminophenol Redox Cycling by Thiols and Tris (2-carboxyethyl) phosphine on Cysteamine-and 3-Mercaptopropionic acid-Covered Gold Electrodes. Int. J. Electrochem. Sci. 2014, 9, 6985-6992.

Miralles, G.; Verdie?, P.; Puget, K.; Maurras, A.; Martinez, J.; Subra, G. Microwave-mediated reduction of disulfide bridges with supported (Tris (2-carboxyethyl) phosphine) as resin-bound reducing agent. ACS Comb. Sci. 2013, 15 (4), 169-173.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H335

Causes severe skin burns and eye damage. May cause respiratory irritation.

Precautionary Statements: P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2931.39
TSCA
No

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