4-Iodo-L-phenylalanine may be used in protein engineering as a model unnatural α amino acid to alter primary amino acid composition via the opal (UGA) codon.
Koichiro Kodama; Dr. Seketsu Fukuzawa; Dr. Kensaku Sakamoto; Dr. Hiroshi Nakayama; Prof. Takanori Kigawa; Takashi Yabuki; Natsuko Matsuda; Dr. Mikako Shirouzu; Dr. Koji Takio; Kazuo Tachibana; Prof. Shigeyuki Yokoyama. A new protein engineering approach combining chemistry and biology, Part I; site-specific incorporation of 4-iodo-L-phenylalanine in vitro by using misacylated suppressor tRNAPhe . ChemBioChem. 2006, 7, (10),1577-1581
Enrico Morera; Giorgio Ortar. A concise synthesis of photoactivatable 4-Aroyl-l-phenylalanines. Bioorganic & Medicinal Chemistry Letters. 2000, 10, (16),1815-1818