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4-fluoro-l-phenylalanine (fF), or 4-trifluoromethyl-l-phenylalanine were introduced inside the chain of peptides to enhances their antimicrobial activity..
Diana Giménez; Cecilia Andreu; Marcel·lí del Olmo;Teresa Varea; Dolores Diaz; Gregorio Asensio. The introduction of fluorine atoms or trifluoromethyl groups in short cationic peptides enhances their antimicrobial activity. Bioorganic & Medicinal Chemistry. 2006, 14(20), 6971-6978.