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Used in the sono gashira reaction which is pd-catalyzed. Precursor in the synthesis of N-substituted 2-aminothiazole derivatives(antitubercular agents).
Giorgio Chelucci,; Salvatore Baldino,; Andrea Ruiu .Room-Temperature Hydrodehalogenation of Halogenated Heteropentalenes with One or Two Heteroatoms. J. Org. Chem., 2012, 77 (21), 9921-9925.
Marco Pieroni,; Baojie Wan,; Sanghyun Cho,; Scott G. Franzblau,; Gabriele Costantino. Design, synthesis and investigation on the structure-activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents . European Journal of Medicinal Chemistry. 2014 , 7226-34.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.