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Chiral dicarboxylic acid guests with a two C spacer (1R,2R)-cyclohexane-1,2-dicarboxylic acid and Boc-L-aspartic acid] gave CD-active species.
Gianfranco Ercolani.The Origin of Cooperativity in Double-Wheel Receptors. Freezing of Internal Rotation or Ligand-Induced Torsional Strain?. Journal name. 2005, 7 (5), 803-805.
Prof. Gianfranco Ercolani,; Dr. Luca Schiaffino. Allosteric, Chelate, and Interannular Cooperativity: A Mise au Point. TOC. 2008, 50 (8), 1762-1768.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.