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(R)-1-Boc-3-hydroxypiperidine has been used as a reactant for the synthesis of piperidinyl and pyrrolidinyl butyrates. It has also been used for the synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors.
Christophe Benard; Rahim Mohammad; Neerja Saraswat; Rudong Shan; Samarendra N.Maiti; Peter G.M.Wuts; Michael Stier; Teresa Lints; James Bradow; Jacob B.Schwarz. Convenient preparation of optically pure 3-aryloxy-pyrrolidines. Synthetic Communications: An International Journal for Rapid Communication of Synthetic Organic Chemistry. 2008, 38, (4),517-524
Nora Liu; Sascha Hoogendoorn; Bas van de Kar; Allard Kaptein; Tjeerd Barf; Christoph Driessen; Dmitri V.Filippov; Gijsbert A. van der Marel; Mario van der Stelt; Herman S.Overkleeft. Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study. Org. Biomol. Chem. 2015, 13, (18),5147-5157
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P260-P201-P280g-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.