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H52792 Lovastatin, 97%

CAS Number
75330-75-5
Synonyms
Mevacor

Stock No. Size Price ($) Quantity Availability
H52792-06 5g 61.90
H52792-14 25g 246.00
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Lovastatin, 97%

MDL
MFCD00072164

Chemical Properties

Formula
C24H36O5
Formula Weight
404.56
Melting point
175°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in DMSO (10 mg/ml), ethanol (10 mg/ml), methanol, chloroform, acetone, acetonitrile, DMF, and water (0.4 µg/ml).

Applications

Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. It causes cell cycle arrest in G1 and G2/M phases.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents and heat.

Literature References

Jonathan A.Tobert. Efficacy and long-term adverse effect pattern of lovastatin. The American Journal of Cardiology. 1988, 62, (15),J28-J34

 

Peter Jones MD; Stephanie Kafonek MD; Irene Laurora PharmD; Donald Hunninghake MD. Comparative Dose Efficacy Study of Atorvastatin VersusSimvastatin, Pravastatin, Lovastatin, and Fluvastatin in Patients With Hypercholesterolemia (The CURVES Study). The American Journal of Cardiology. 1998, 81, (5),582-587

GHS Hazard and Precautionary Statements

Hazard Statements: H317-H351-H361d

May cause an allergic skin reaction. Suspected of causing cancer. Suspected of damaging the unborn child.

Precautionary Statements: P201-P202-P261-P272-P280g-P281-P302+P352-P308+P313-P333+P313-P363-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. Use personal protective equipment as required. IF ON SKIN: Wash with plenty of soap and water. IF exposed or concerned: Get medical advice/attention. If skin irritation or rash occurs: Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2932.20
TSCA
No
RTECS
EK7907000

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