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Lovastatin is a cholesterol lowering drug and competitive inhibitor of HMG-CoA reductase, a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. It increases cellular resistance to anticancer agents such as doxorubicin and induces apoptosis in myeloma cells. It causes cell cycle arrest in G1 and G2/M phases.
Jonathan A.Tobert. Efficacy and long-term adverse effect pattern of lovastatin. The American Journal of Cardiology. 1988, 62, (15),J28-J34
Peter Jones MD; Stephanie Kafonek MD; Irene Laurora PharmD; Donald Hunninghake MD. Comparative Dose Efficacy Study of Atorvastatin VersusSimvastatin, Pravastatin, Lovastatin, and Fluvastatin in Patients With Hypercholesterolemia (The CURVES Study). The American Journal of Cardiology. 1998, 81, (5),582-587
Hazard Statements: H317-H351-H361d
May cause an allergic skin reaction. Suspected of causing cancer. Suspected of damaging the unborn child.
Precautionary Statements: P201-P202-P261-P272-P280g-P281-P302+P352-P308+P313-P333+P313-P363-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. Use personal protective equipment as required. IF ON SKIN: Wash with plenty of soap and water. IF exposed or concerned: Get medical advice/attention. If skin irritation or rash occurs: Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant