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761446-44-0 - 1-Methyl-1H-pyrazole-4-boronic acid pinacol ester, 97% - 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole - H53139 - Alfa Aesar

H53139 1-Methyl-1H-pyrazole-4-boronic acid pinacol ester, 97%

CAS Number

Size Price ($) Quantity Availability
250mg 36.16
1g 130.50
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1-Methyl-1H-pyrazole-4-boronic acid pinacol ester, 97%


Chemical Properties

Formula Weight
Melting point
Slightly soluble in water.


It is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.


Store in cool dry place. Ensure proper ventilation. Incompatible with oxidizing agents.

Literature References

Peter R. Mullens. An improved synthesis of 1-methyl-1H-pyrazole-4-boronic acid pinacol ester and its corresponding lithium hydroxy ate complex: application in Suzuki couplingsTetrahedron Lett 2009, 50 (49),6783-6786 .

Minhang Xin.; Jun Wen.; Feng Tang.; Chongxing Tu.; Han Shen.; Xinge Zhao. The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors.bioorg med chem lett. 2013, 23 (24), 6777-6783 .

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P301+P310-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code


  • L19654

    1H-Pyrazole-4-boronic acid pinacol ester, 98%

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