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H53451 3-Bromo-1-trimethylsilyl-1-propyne, 98%

CAS Number
38002-45-8
Synonyms
3-(Trimethylsilyl)propargyl bromide

Stock No. Size Price ($) Quantity Availability
H53451-06 5g 78.20
H53451-14 25g 306.00
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3-Bromo-1-trimethylsilyl-1-propyne, 98%

MDL
MFCD00134460

Chemical Properties

Formula
C6H11BrSi
Formula Weight
191.14
Boiling Point
44-45°/2mm
Flash Point
63°(145°F)
Density
1.17
Refractive Index
1.483
Storage & Sensitivity
Ambient temperatures.
Solubility
Immiscible with water.

Applications

3-Bromo-1-trimethylsilyl-1-propyne is used in the preparation of tetrahydroisoquinoline-3-carboxylic acid derivatives. It acts as a propargylating agent and used for the alkylation of dianion of beta-keto esters at gamma-carbon. It plays an important role in the synthesis of allenic alcohols and terminal conjugated enynes.

Notes

Store in cool place. Incompatible with strong oxidizing agents.

Literature References

Wanat, P.; Walczak, S.; Wojtczak, B. A.; Nowakowska, M.; Jemielity, J.; Kowalska, J. Ethynyl, 2-Propynyl, and 3-Butynyl C-Phosphonate Analogues of Nucleoside Di- and Triphosphates: Synthesis and Reactivity in CuAAC. Org. Lett. 2015, 17 (12), 3062-3065.

Guo, T.; Liu, Y.; Li, B.; Liu, H. Convenient synthesis of α,α-(bisallyl and bispropargyl)-substituted amines via aza-Barbier-type reaction. Tetrahedron Lett. 2015, 56 (19), 2469-2471.

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H315-H319-H335

Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210-P235-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep cool. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
2037650
Harmonized Tariff Code
2931.90
TSCA
No

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