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38002-45-8 - 3-Bromo-1-trimethylsilyl-1-propyne, 98% - 3-(Trimethylsilyl)propargyl bromide - H53451 - Alfa Aesar

H53451 3-Bromo-1-trimethylsilyl-1-propyne, 98%

CAS Number
38002-45-8
Synonyms
3-(Trimethylsilyl)propargyl bromide

Size Price ($) Quantity Availability
5g 70.60
25g 280.00
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3-Bromo-1-trimethylsilyl-1-propyne, 98%

MDL
MFCD00134460

Chemical Properties

Formula
C6H11BrSi
Formula Weight
191.14
Boiling Point
44-45°/2mm
Flash Point
63°(145°F)
Density
1.17
Refractive Index
1.483
Solubility
Immiscible with water.

Applications

3-Bromo-1-trimethylsilyl-1-propyne is used in the preparation of tetrahydroisoquinoline-3-carboxylic acid derivatives. It acts as a propargylating agent and used for the alkylation of dianion of beta-keto esters at gamma-carbon. It plays an important role in the synthesis of allenic alcohols and terminal conjugated enynes.

Notes

Store in cool place. Incompatible with strong oxidizing agents.

Literature References

Wanat, P.; Walczak, S.; Wojtczak, B. A.; Nowakowska, M.; Jemielity, J.; Kowalska, J. Ethynyl, 2-Propynyl, and 3-Butynyl C-Phosphonate Analogues of Nucleoside Di- and Triphosphates: Synthesis and Reactivity in CuAAC. Org. Lett. 2015, 17 (12), 3062-3065.

Guo, T.; Liu, Y.; Li, B.; Liu, H. Convenient synthesis of α,α-(bisallyl and bispropargyl)-substituted amines via aza-Barbier-type reaction. Tetrahedron Lett. 2015, 56 (19), 2469-2471.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335-H227

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Precautionary Statements: P210-P261-P280-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
2037650
Harmonized Tariff Code
2931.90
TSCA
No

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