6-Chloro-2-hexanone in the synthesis of the keto analogs began with 6-chloro-2-hexanone. Substituted 7-(oxoalkyl)theophyllines were synthesized by alkylation of the respective theophyllines with 6-chloro-2-hexanone.
Dubey, P K,; Naidu, A,; Anandam, V,; Hemasunder, G. Synthesis of 1-(n-hexyl-5-one)-2-chlorobenzimidazole. (IJC-B).2005, 44B1239-1242.
A. Rybar,; P. Turcani,; J. Alfoldi. 8-Substituted 7-(Oxoalkyl) theophyllines. Journal name. 1993, .
Hazard Statements: H227-H315-H319-H335
Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210u-P261-P280a-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.