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Propargylamine is used in the synthesis of a chiral, a fluorescent macrocycle by 1,3-dipolar cycloaddition of propargyl amides of carbohydrate-linked amino acids and 9,10-bis(azidomethyl)anthracene. It acts as an intermediate in the production of drugs.
He, Y.; Liang, Y.; Wang, D. The highly sensitive and facile colorimetric detection of the glycidyl azide polymer based on propargylamine functionalized gold nanoparticles using click chemistry. Chem. Commun. 2015, 51 (60), 12092-12094.
Zindo, F.; Joubert, J.; Malan, S. Polycyclic propargylamine derivatives as multifunctional neuroprotective agents: cum laude. S Afr. Pharm. J. 2015, 82 (2), 32-34.
Hazard Statements: H225-H302-H311-H314
Highly flammable liquid and vapour. Harmful if swallowed. Toxic in contact with skin. Causes severe skin burns and eye damage.
Precautionary Statements: P210-P233-P240-P241-P242-P243-P260-P264b-P270-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant