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H54035 O-(N-Succinimidyl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 98+%

CAS Number
265651-18-1
Synonyms
N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate
HSTU

Stock No. Size Price ($) Quantity Availability
H54035-03 1g 41.70
H54035-06 5g 166.00
H54035-14 25g 645.00
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O-(N-Succinimidyl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 98+%

MDL
MFCD01863753

Chemical Properties

Formula
C9H16F6N3O3P
Formula Weight
359.21
Melting point
ca 220° dec.
Storage & Sensitivity
Store at -20°C. Moisture Sensitive. Store under Nitrogen.
Solubility
Soluble in acetonitrile 0.5 g/mL.

Applications

Coupling reagent for peptide synthesis and the formation of other amides. Reactant for synthesis of liposomal contrast agents for magnetic resonance imaging, synthesis of protein labeling molecules, synthesis of thiol-reactive Cy5 derivatives.

Notes

Moisture sensitive. Store under inert gas. Store away from oxidizing agents, water/ moisture.

Literature References

H J Gruber; G Kada; B Pragl; C Riener; C D Hahn; G S Harms; W Ahrer; T G Dax; K Hohenthanner; H G Knaus. Preparation of thiol-reactive Cy5 derivatives from commercial Cy5 succinimidyl ester. Bioconjugate Chemistry. 2000, 11 (2), 161-166.

Sjoerd Hak; Honorius M H F Sanders; Prashant Agrawal; Sander Langereis; Holger Grüll; Henk M Keizer; Francesca Arena; Enzo Terreno; Gustav J Strijkers; Klaas Nicolay. A high relaxivity Gd(III)DOTA-DSPE-based liposomal contrast agent for magnetic resonance imaging. European Journal of Pharmaceutics and Biopharmaceutics. 2009, 72 (2), 397-404.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2925.19
TSCA
No

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