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H54035 O-(N-Succinimidyl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 98+%

CAS Number
N,N,N',N'-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate

Stock No. Size Price ($) Quantity Availability
H54035-03 1g 41.70
H54035-06 5g 166.00
H54035-14 25g 645.00
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O-(N-Succinimidyl)-N,N,N',N'-tetramethyluronium hexafluorophosphate, 98+%


Chemical Properties

Formula Weight
Melting point
ca 220° dec.
Storage & Sensitivity
Store at -20°C. Moisture Sensitive. Store under Nitrogen.
Soluble in acetonitrile 0.5 g/mL.


Coupling reagent for peptide synthesis and the formation of other amides. Reactant for synthesis of liposomal contrast agents for magnetic resonance imaging, synthesis of protein labeling molecules, synthesis of thiol-reactive Cy5 derivatives.


Moisture sensitive. Store under inert gas. Store away from oxidizing agents, water/ moisture.

Literature References

H J Gruber; G Kada; B Pragl; C Riener; C D Hahn; G S Harms; W Ahrer; T G Dax; K Hohenthanner; H G Knaus. Preparation of thiol-reactive Cy5 derivatives from commercial Cy5 succinimidyl ester. Bioconjugate Chemistry. 2000, 11 (2), 161-166.

Sjoerd Hak; Honorius M H F Sanders; Prashant Agrawal; Sander Langereis; Holger Grüll; Henk M Keizer; Francesca Arena; Enzo Terreno; Gustav J Strijkers; Klaas Nicolay. A high relaxivity Gd(III)DOTA-DSPE-based liposomal contrast agent for magnetic resonance imaging. European Journal of Pharmaceutics and Biopharmaceutics. 2009, 72 (2), 397-404.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

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