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125700-69-8 - N,N,N',N'-Tetramethyl-O-(4-oxo-3,4-dihydro-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate, 98+% - O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate - TDBTU - H54144 - Alfa Aesar

H54144 N,N,N',N'-Tetramethyl-O-(4-oxo-3,4-dihydro-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate, 98+%

CAS Number
125700-69-8
Synonyms
O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate
TDBTU

Size Price ($) Quantity Availability
1g 39.70
5g 175.00
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N,N,N',N'-Tetramethyl-O-(4-oxo-3,4-dihydro-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate, 98+%

MDL
MFCD00077730

Chemical Properties

Formula
C12H16BF4N5O2
Formula Weight
349.09
Sensitivity
Moisture & Light Sensitive
Solubility
Soluble in acetonitrile 0.1 g/mL.

Applications

O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N?,N?-tetramethyluronium tetrafluoroborate (2-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, TBTU) may be used as coupling reagent in the synthesis of macrocyclic polyamine derivatives with various length of linkers, condensation reagent in the large-scale preparation of the hematoregulatory nonapeptide (Glp-Glu-Asp)2-DAS-(Lys)2 (2,SK&F 107647), coupling reagent for peptide synthesis which best suppresses racemization during fragment condensation.

Notes

Moisture and light sensitive. Store away from water/ moisture, oxidizing agents. Protect from heat.

Literature References

J Hiebl, D P Alberts; A F Banyard; K Baresch; H Baumgartner; I Bernwieser; P K Bhatnagar; M Blanka; M Bodenteich; T Chen; P M Esch; H Kollmann; I Lantos; K Leitner; G Mayrhofer; R Patel; A Rio; F Rovenszky; D Stevenson; K D Tubman; K Undheim; H Weihtrager; W Welz; K Winkler. Large-scale synthesis of hematoregulatory nonapeptide SK&F 107647 by fragment coupling. Journal of Peptide Research. 1999, 54 (1), 54-65.

Cuihua Liu; Hudson Robert H. E.; Petersen Nils O. Convergent and sequential synthesis of dendritic, multivalent complexing agents. Synthesis. 2002, (10), 1398-1406.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2933.99
TSCA
No

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