Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

H54144 N,N,N',N'-Tetramethyl-O-(4-oxo-3,4-dihydro-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate, 98+%

CAS Number
125700-69-8
Synonyms
O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate
TDBTU

Stock No. Size Price ($) Quantity Availability
H54144-03 1g 41.00
H54144-06 5g 179.00
Add to Cart Bulk/Specialty Print Quote View Item

N,N,N',N'-Tetramethyl-O-(4-oxo-3,4-dihydro-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate, 98+%

MDL
MFCD00077730

Chemical Properties

Formula
C12H16BF4N5O2
Formula Weight
349.09
Storage & Sensitivity
Keep Cold. Moisture Sensitive. Light Sensitive. Store under Nitrogen.
Solubility
Soluble in acetonitrile 0.1 g/mL.

Applications

O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N?,N?-tetramethyluronium tetrafluoroborate (2-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, TBTU) may be used as coupling reagent in the synthesis of macrocyclic polyamine derivatives with various length of linkers, condensation reagent in the large-scale preparation of the hematoregulatory nonapeptide (Glp-Glu-Asp)2-DAS-(Lys)2 (2,SK&F 107647), coupling reagent for peptide synthesis which best suppresses racemization during fragment condensation.

Notes

Moisture and light sensitive. Store away from water/ moisture, oxidizing agents. Protect from heat.

Literature References

J Hiebl, D P Alberts; A F Banyard; K Baresch; H Baumgartner; I Bernwieser; P K Bhatnagar; M Blanka; M Bodenteich; T Chen; P M Esch; H Kollmann; I Lantos; K Leitner; G Mayrhofer; R Patel; A Rio; F Rovenszky; D Stevenson; K D Tubman; K Undheim; H Weihtrager; W Welz; K Winkler. Large-scale synthesis of hematoregulatory nonapeptide SK&F 107647 by fragment coupling. Journal of Peptide Research. 1999, 54 (1), 54-65.

Cuihua Liu; Hudson Robert H. E.; Petersen Nils O. Convergent and sequential synthesis of dendritic, multivalent complexing agents. Synthesis. 2002, (10), 1398-1406.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2933.99
TSCA
No

Recommended

  • A14338

    4-Dimethylaminobenzoic acid, 98+%
  • J61491

    Amphotericin B, Streptomyces nodosus

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware