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H54144 N,N,N',N'-Tetramethyl-O-(4-oxo-3,4-dihydro-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate, 98+%

CAS Number
O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

Stock No. Size Price ($) Quantity Availability
H54144-03 1g 41.00
H54144-06 5g 179.00
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N,N,N',N'-Tetramethyl-O-(4-oxo-3,4-dihydro-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate, 98+%


Chemical Properties

Formula Weight
Storage & Sensitivity
Keep Cold. Moisture Sensitive. Light Sensitive. Store under Nitrogen.
Soluble in acetonitrile 0.1 g/mL.


O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N?,N?-tetramethyluronium tetrafluoroborate (2-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, TBTU) may be used as coupling reagent in the synthesis of macrocyclic polyamine derivatives with various length of linkers, condensation reagent in the large-scale preparation of the hematoregulatory nonapeptide (Glp-Glu-Asp)2-DAS-(Lys)2 (2,SK&F 107647), coupling reagent for peptide synthesis which best suppresses racemization during fragment condensation.


Moisture and light sensitive. Store away from water/ moisture, oxidizing agents. Protect from heat.

Literature References

J Hiebl, D P Alberts; A F Banyard; K Baresch; H Baumgartner; I Bernwieser; P K Bhatnagar; M Blanka; M Bodenteich; T Chen; P M Esch; H Kollmann; I Lantos; K Leitner; G Mayrhofer; R Patel; A Rio; F Rovenszky; D Stevenson; K D Tubman; K Undheim; H Weihtrager; W Welz; K Winkler. Large-scale synthesis of hematoregulatory nonapeptide SK&F 107647 by fragment coupling. Journal of Peptide Research. 1999, 54 (1), 54-65.

Cuihua Liu; Hudson Robert H. E.; Petersen Nils O. Convergent and sequential synthesis of dendritic, multivalent complexing agents. Synthesis. 2002, (10), 1398-1406.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code


  • A14338

    4-Dimethylaminobenzoic acid, 98+%
  • J61491

    Amphotericin B, Streptomyces nodosus

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