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H54187 3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one, 97%

CAS Number
55314-16-4
Synonyms

Stock No. Size Price ($) Quantity Availability
H54187-MD 250mg 18.70
H54187-03 1g 55.20
H54187-06 5g 219.00
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3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one, 97%

MDL
MFCD00115180

Chemical Properties

Formula
C10H12N2O
Formula Weight
176.22
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in chloroform and dichloromethane.

Applications

3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one is used ads pharmaceutical intermediate, an imatinib intermediate.

Notes

Store in a cool, dry place, in a well sealed container. Store away from oxidizing agents, acids bases.

Literature References

Jürg Zimmermann; Elisabeth Buchdunger; Helmut Mett; Thomas Meyer; Nicholas B. Lydon; Peter Traxler. Phenylamino-pyrimidine (PAP) — derivatives: a new class of potent and highly selective PDGF-receptor autophosphorylation inhibitors. Bioorganic & Medicinal Chemistry Letters. 1996, 6 (11), 1221-1226.

Rao, R Janaki Rama; S, A K; Rao, Bhujanga; Swapna, K; Rani, B Baby Rani; and Y.L.N. Murthy. Synthesis and Antimicrobial Activity of Novel 7-(Heteroaryl)-1,2,4-triazolo[1,5-a]-pyrimidine Derivatives. Asian Journal of Chemistry. 2012, 24 (4),1837-1843.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2933.39
TSCA
No

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