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H54378 (7-Aza-1H-benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 99+%

CAS Number
156311-83-0
Synonyms
PyAOP

Stock No. Size Price ($) Quantity Availability
H54378-03 1g 65.00
H54378-06 5g 256.00
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(7-Aza-1H-benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 99+%

MDL
MFCD03703417

Chemical Properties

Formula
C17H27F6N7OP2
Formula Weight
521.38
Melting point
163-168°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in water.

Applications

(7-Aza-1H-benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphonium hexafluorophosphate is used as reagent for synthesis of cyclic RGC pentapeptides for functionalization through click chemistry, fluorescent glucose bioprobes and ReactIR™ flow cell. It is also used as reagent for disulfide bond engineering, heteroaryl ether synthesis and optimization of conformational constraint on non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.

Notes

Stable under recommended storage conditions. Store away from oxidizing agents.

Literature References

Hyang Yeon Lee; Jae Jeong Lee; Jongmin Park; Seung Bum Park. Development of fluorescent glucose bioprobes and their application on real-time and quantitative monitoring of glucose uptake in living cells. Chemistry: A European Journal. 2011, 17, (1),143-150

 

Markus Muttenthaler; Asa Andersson; Aline D de Araujo; Zoltan Dekan; Richard J.Lewis; Paul F.Alewood. Modulating oxytocin activity and plasma stability by disulfide bond engineering. Journal of medicinal and pharmaceutical chemistry. 2010, 53, (24),8585-8596

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2933.99
TSCA
No
RTECS
TH3890000

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