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146998-31-4 - 4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester, 98+% - DABCYL-N-succinimidyl ester - 4-[(Dimethylamino)azo]benzene-4'-carboxylic acid N-succinimidyl ester - H54402 - Alfa Aesar

H54402 4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester, 98+%

CAS Number
146998-31-4
Synonyms
DABCYL-N-succinimidyl ester
4-[(Dimethylamino)azo]benzene-4'-carboxylic acid N-succinimidyl ester

Size Price ($) Quantity Availability
25mg 41.70
100mg 134.00
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4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester, 98+%

MDL
MFCD00467415

Chemical Properties

Formula
C19H18N4O4
Formula Weight
366.37
Sensitivity
Moisture Sensitive
Solubility
Soluble in DMSO.

Applications

4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester is a useful reagent (similar to MANCYL-SE) for labeling proteins or peptides through their amino-groups by forming stable peptide bonds. The succinimidyl ester is reactive with terminal amines or lysines of peptides and other nucleophiles for fluorescent studies of proteins. Its fluorescent properties (has a characteristic broad and intense visible absorption but has no fluorescence) make it an ideal long wavelength quencher and it has been utilized as an acceptor chromophore in FRET studies. It is also used for N-terminal modification of peptides in automated synthesis.

Notes

Moisture sensitive. Incompatible with oxidizing agents and heat.

Literature References

Desmond J O'Shea; Tomas C O'Riordan; Paul J O'Sullivan; Dmitri B.Papkovsky. Homogeneous time-resolved fluorescence assays for the detection of activity and inhibition of phosphatase enzymes employing phosphorescently labeled peptide substrates. Analytica Chimica Acta. 2007, 583,(2), 349-356.

 

Tomas C O'Riordan; James Hynes; Dmitri Yashunski; Gelii V.Ponomarev; Dmitri B.Papkovsky. Homogeneous assays for cellular proteases employing the platinum(II)-coproporphyrin label and time-resolved phosphorescence. Analytical Biochemistry. 2005, 342,(1), 111-119.

Other References

Harmonized Tariff Code
2927.00
TSCA
No

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