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2-Aminopyrimidine-5-boronic acid pinacol ester is used in the preparation of phosphoinositide-3-kinases (PI3K) inhibitors.
Wan-Kyu Oh.; Yoon Seon Jeong.; Sojin Kim.; Jyongsik Jang. Fluorescent Polymer Nanoparticle for Selective Sensing of Intracellular Hydrogen Peroxide. ACS Nano. 2012, 6 (10),8516-8524.
Timothy P. Heffron.; Megan Berry.; Georgette Castanedo.; Christine Chang.; Irina Chuckowree.; Jennafer Dotson.; Adrian Folkes.; Janet Gunzner.; John D. Lesnick.; Cristina Lewis.; Simon Mathieu.; Jim Nonomiya.; Alan Olivero.; Jodie Pang.; David Petersonc.; Laurent Salphati.; Deepak Sampath.; Steve Sideris.; Daniel P. Sutherlin.; Vickie Tsui.; Nan Chi Wan.; Shumei Wang.; Susan Wong. Bing-yan Zhu. Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor. Bioorg. Med. Chem. Lett. 2010, 20 (8),2408-2411.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant