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H54451 2-Aminopyrimidine-5-boronic acid pinacol ester, 96%

CAS Number
402960-38-7
Synonyms

Stock No. Size Price ($) Quantity Availability
H54451-MD 250mg 31.50
H54451-03 1g 103.00
H54451-06 5g 473.00
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2-Aminopyrimidine-5-boronic acid pinacol ester, 96%

MDL
MFCD06795685

Chemical Properties

Formula
C10H16BN3O2
Formula Weight
221.06
Melting point
206-208°
Storage & Sensitivity
Keep Cold. Store under Argon.
Solubility
Slightly soluble in water. Soluble in chloroform.

Applications

2-Aminopyrimidine-5-boronic acid pinacol ester is used in the preparation of phosphoinositide-3-kinases (PI3K) inhibitors.

Notes

Incompatible with strong oxidizing agents, reducing agents and acids. Store at 4-2°C.

Literature References

Wan-Kyu Oh.; Yoon Seon Jeong.; Sojin Kim.; Jyongsik Jang. Fluorescent Polymer Nanoparticle for Selective Sensing of Intracellular Hydrogen Peroxide. ACS Nano. 2012, 6 (10),8516-8524.

Timothy P. Heffron.; Megan Berry.; Georgette Castanedo.; Christine Chang.; Irina Chuckowree.; Jennafer Dotson.; Adrian Folkes.; Janet Gunzner.; John D. Lesnick.; Cristina Lewis.; Simon Mathieu.; Jim Nonomiya.; Alan Olivero.; Jodie Pang.; David Petersonc.; Laurent Salphati.; Deepak Sampath.; Steve Sideris.; Daniel P. Sutherlin.; Vickie Tsui.; Nan Chi Wan.; Shumei Wang.; Susan Wong. Bing-yan Zhu. Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor. Bioorg. Med. Chem. Lett. 2010, 20 (8),2408-2411.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2934.99
TSCA
No

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