Quinuclidine acts as a catalyst, a chemical building block and is used in organic synthesis. It is employed to prepare quinine and alkaloids. It finds application as a ligand, which is useful in the studies of OsO4-catalyzed dihydroxylation of olefins. It plays an important role in the formation of onium salts used testing of PAC-antagonist activity.
Chan, F. Y.; Sun, N.; Leung, Y. C.; Wong, K. Y. Antimicrobial activity of a quinuclidine-based FtsZ inhibitor and its synergistic potential with beta-lactam antibiotics. J. Antibiot. 2015, 68 (4), 253-258.
Reddi, Y.; Sunoj, R. B. Asymmetric Dual-Catalytic Cascade by Chiral N-Heterocyclic Carbene and Quinuclidine: Mechanism and Origin of Enantioselectivity in Benzofuranone Formation. ACS Catal. 2015, 5 (3), 1596-1603.
Hazard Statements: H301-H310-H315-H318
Toxic if swallowed. Fatal in contact with skin. Causes skin irritation. Causes serious eye damage.
Precautionary Statements: P262-P280-P301+P310a-P305+P351+P338-P405-P501a
Do not get in eyes, on skin, or on clothing. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.