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Ethidium bromide efficiently intercalates into synthetic duplex DNAs with 7-deazaguanine in place of guanine, but shows none of the fluorescence enhancement usually observed upon intercalation. 7-Deazaadenine-duplexes show about 70% of the expected fluorescence enhancement.
L J Latimer.; J S Lee. Ethidium bromide does not fluoresce when intercalated adjacent to 7-deazaguanine in duplex DNA. The Journal of Biological Chemistry. 1991, 26613849-13851..
Nabih S. Girgis.; Maged A. Michael.; Donald F. Smee.; Hassan A. Alaghamandan.; Roland K. Robins.; Howard B. Cottam. Direct C-glycosylation of guanine analogs: the synthesis and antiviral activity of certain 7- and 9-deazaguanine C-nucleosides.J. Med. Chem. 1990, 33 (11),2750-2755.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.