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H54595 7-Deazaguanine, 97%

CAS Number
7355-55-7
Synonyms
2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine

Stock No. Size Price ($) Quantity Availability
H54595-MD 250mg 281.00
H54595-03 1g 1009.00
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7-Deazaguanine, 97%

MDL
MFCD00079103

Chemical Properties

Formula
C6H6N4O
Formula Weight
150.14
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in N,N-Dimethylformamide, Dimethyl sulfoxide.

Applications

Ethidium bromide efficiently intercalates into synthetic duplex DNAs with 7-deazaguanine in place of guanine, but shows none of the fluorescence enhancement usually observed upon intercalation. 7-Deazaadenine-duplexes show about 70% of the expected fluorescence enhancement.

Notes

Store at room temperature. Keep away from oxidizing agents and acids.

Literature References

L J Latimer.; J S Lee. Ethidium bromide does not fluoresce when intercalated adjacent to 7-deazaguanine in duplex DNA. The Journal of Biological Chemistry. 1991, 26613849-13851..

Nabih S. Girgis.; Maged A. Michael.; Donald F. Smee.; Hassan A. Alaghamandan.; Roland K. Robins.; Howard B. Cottam. Direct C-glycosylation of guanine analogs: the synthesis and antiviral activity of certain 7- and 9-deazaguanine C-nucleosides.J. Med. Chem. 1990, 33 (11),2750-2755.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
512680
Harmonized Tariff Code
2933.59
TSCA
No

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