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3-Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt is a cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
Wolfgang J. Parak.; Daniele Gerion.; Daniela Zanchet.; Anke S. Woerz.; Teresa Pellegrino.; Christine Micheel.; Shara C. Williams.; Markus Seitz.; Richard E. Bruehl.; Zev Bryant.; Carlos Bustamante.; Carolyn R. Bertozzi.; A. Paul Alivisatos. Conjugation of DNA to Silanized Colloidal Semiconductor Nanocrystalline Quantum Dots. Chem. Mater. 2002, 14 (5), 2113-2119.
Tsuyoshi Tanaka.; Tadashi Matsunaga. Fully Automated Chemiluminescence Immunoassay of Insulin Using Antibody-Protein A-Bacterial Magnetic Particle Complexes. Anal. Chem. 2000, 72 (15), 3518-3522.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.