2-Amino-4-chloropyrimidine is a substrate used in a palladium-catalyzed cyanation with zinc(II) cyanide. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.
Adam Littke.; Maxime Soumeillant.; Robert F Kaltenbach Iii.; Robert J Cherney.; Christine M Tarby.; Susanne Kiau. Mild and general methods for the palladium-catalyzed cyanation of aryl and heteroaryl chlorides. Chemical Communications. 2007, 9 (9), 1711-1714.
C. Kenneth Banks. Arylaminoheterocyclic Compounds. I. Synthetic Method. J. Am. Chem. Soc. 1944, 66 (7), 1127-1130.
Hazard Statements: H302-H315-H318-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye damage. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.