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1,1'-Diethyl-2,2'-cyanine iodide is used to inhibit 1-methyl-4-phenylpyridinium (MPP+), toxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine that induces apoptosis in cerebellar granule neurons (CGNs).
Jiro Tanaka.; Masashi Tanaka.; Masuo Hayakawa. Electronic Spectra of Single Crystals of 1,1?-Diethyl-2,2?-Cyanine Iodide, Bromide, and Chloride. Bulletin of the Chemical Society of Japan. 1980, 53 (11), 3109-3119.
Irina A. Struganova.; Mesha Hazell.; Jacinta Gaitor.; Debra McNally-Carr.; Sanja Zivanovic. Influence of Inorganic Salts and Bases on the J-Band in the Absorption Spectra of Water Solutions of 1,1-Diethyl-2,2-cyanine Iodide. Chemical Communications. 2003, 107 (15), 2650-2656.
Hazard Statements: H300-H312-H330-H315-H319-H335
Fatal if swallowed. Harmful in contact with skin. Fatal if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P301+P310a-P304+P340-P305+P351+P338-P320-P330-P405-P501a
IF SWALLOWED: IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.