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62802-42-0 - 2-Chloro-5-fluoropyrimidine, 97% - H55055 - Alfa Aesar

H55055 2-Chloro-5-fluoropyrimidine, 97%

CAS Number
62802-42-0
Synonyms

Size Price ($) Quantity Availability
250mg 44.70
1g 148.00
5g 614.00
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2-Chloro-5-fluoropyrimidine, 97%

MDL
MFCD03788197

Chemical Properties

Formula
C4H2ClFN2
Formula Weight
132.52
Flash Point
65°(149°F)
Density
1.073
Refractive Index
1.5030

Applications

2-Chloro-5-fluoropyrimidine is used to prepare 2,4-disubstituted-5-fluoropyrimidine , which is a biologically active molecule seen in anticancer agents like 5-fluorouracil.

Notes

Incompatible with strong oxidizing agents.

Literature References

Witt, A.; Teodorovic, P.; Linderberg, M.; Johansson, P.; Minidis, A. A Novel scalable process to the GSK3 β inhibitor AZD8926 based on a heterocyclic ziegler coupling. Org. Process Res. Dev. 2013, 17 (4), 672-678.

Stock, N. S.; Bain, G.; Zunic, J.; Li, Y.; Ziff, J.; Roppe, J.; Santini, A.; Darlington, J.; Prodanovich, P.; King, C. D.; Baccei, C.; Lee, C.; Rong, H.; Chapman, C.; Broadhead, A.; Lorrain, D.; Correa, L.; Hutchinson, J. H.; Evans, J. F.; Prasit, P. 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors. Part 4: Development of 3-[3-tert-Butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl) benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1 H-indol-2-yl]-2, 2-dimethylpropionic Acid (AM803), a Potent, Oral, Once Daily FLAP Inhibitor. J. Med. Chem. 2011, 54 (23), 8013-8029.

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H301-H314-H318

Combustible liquid. Toxic if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.

Precautionary Statements: P210u-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2933.59
TSCA
No

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