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2,4-Dichloro-5-methylpyrimidine, is used in the synthesis of (2-chloro-6-methyl-pyrimidin-4-yl)-(2,3-dihydro-benzothiazol-6-yl)-amine. It can react with piperidineto produce 2-chloro-5-methyl-4-piperidin-1-yl-pyrimidine. This reaction will need solvent dioxane.
Henry C. Koppel.; Robert Henre Springer.; Roland K. Robins.; C. C. Cheng. Pyrimidines. V. Analogs of 2-(o-Chlorobenzylthio)-4-dimethylamino- 5-methylpyrimidine (Bayer DG-428)1. J. Org. Chem. 1962, 27, 91), 181-185.
Bryan W. Roberts.; Joseph B. Lambert.; John D. Roberts. Nitrogen-15 Magnetic Resonance Spectroscopy. VI. Pyrimidine Derivatives1,2. J. Am. Chem. Soc. 1965, 87, (23), 5439-5441.
Hazard Statements: H314-H335
Causes severe skin burns and eye damage. May cause respiratory irritation.
Precautionary Statements: P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant