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Agmatine is an intermediate in the biosynthesis of the polyamines putrescine and spermine. Agmatine binds with high affinity to α2-adrenergic receptors and imidazoline binding sites and produces blockade of the NMDA-receptor associated cation channels. Agmatine is a competitive inhibitor of nitric oxide synthase activity owing to mimicry of the natural NOS substrate arginine.
Yoko Sakakibara.; Hiroshi Yanagisawa. Agmatine deiminase from cucumber seedlings is a mono-specific enzyme: purification and characteristics. Protein Expression and Purification. 2003, 30, (1), 88-93.
Kazuho Abe.; Yuzuru Abe.; Hiroshi Saito. Agmatine suppresses nitric oxide production in microglia. Brain Research. 2000, 872, (1-2), 141-148.