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5-Bromo-2-chloroanisole is used to produce 4-chloro-3-methoxy-benzonitrile at the temperature of 110°C. It will need solvent dimethylformamide
Walfred S. Saari.; June. Williams.; Susan F. Britcher.; Donald E. Wolf.; Frederick A. Kuehl. Tyrosine Hydroxylase Inhibitors. Synthesis and Activity of Substituted Aromatic Amino Acids. J. Med. Chem. 1967, 10, (6), 1008-1014.