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5-Chlorovaleroyl chloride (5-CVC) has been used in the development and validation of a GC-FID method for the analysis of low level impurities present in 5-CVC. It has been used in the synthesis of anion-exchange resins by acylation of polystyrene/divinylbenzene and subsequent amination with trimethylamine. It is commonly used as alkylating agent in the synthesis of pharmaceutical intermediates and other specialty chemicals.
Liya Tang.; Alexandre Kim.; Scott A. Miller.; David K. Lloyd. Development and validation of a specific and sensitive GC-FID method for the determination of impurities in 5-chlorovaleroyl chloride.J. Pharm. Biomed. Anal. 2010, 53 (3), 309-314.
T. N. Kasyanova.; A. D. Smolenkov.; A. V. Pirogov.; O. A. Shpigun. Effect of the acylating agent on the selectivity of anion-exchange resins and separation efficiency. Moscow University Chemistry Bulletin. 2007, 62 (5), 286-289.
Hazard Statements: H227-H302-H314-H318
Combustible liquid. Harmful if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P210u-P260u-P303+P361+P353-P305+P351+P338-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.