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H57150 (S)-(-)-1-Boc-2-cyanopyrrolidine, 95%

CAS Number
228244-04-0
Synonyms
(S)-(-)-1-Boc-pyrrolidine-2-carbonitrile

Stock No. Size Price ($) Quantity Availability
H57150-MD 250mg 59.50
H57150-03 1g 204.00
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(S)-(-)-1-Boc-2-cyanopyrrolidine, 95%

MDL
MFCD01861224

Chemical Properties

Formula
C10H16N2O2
Formula Weight
196.25
Melting point
33-36°
Flash Point
110°(230°F)
Storage & Sensitivity
Moisture Sensitive. Light Sensitive. Store under Argon. Ambient temperatures.
Solubility
Slightly soluble in water.

Applications

(S)-(-)-1-Boc-2-pyrrolidinecarbonitrile is used in synthesis of prolyl oligopeptidase inhibitors and is a reagent that is used in the design of potent and selective inhibitors of DPP-4 that exhibits an attractive pharmacokinetic profile as antidiabetics.

Notes

Moisture and light sensitive. Store away from light, water/moisture and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store in dark.

Literature References

Erik A A Wallén, et al. New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides.J. Med. Chem.,2003,46(21), 4543-4551.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H312-H315-H319-H332-H335

Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. Harmful if inhaled. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2933.99
TSCA
No

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