4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide is involved in long-chain fatty acid stimulated GLP-1 secretion and has been implicated in glucose homeostasis, adiposity, and regulation of the anti-inflammatory response. It enhances glucose-stimulated insulin secretion in MIN6 cells. It induces intracellular calcium accumulation in U2OS cells; this activity is inhibited by AH 7614.
Da Young Oh; Evelyn Walenta. Omega-3 Fatty Acids and FFAR4. Frontiers in Endocrinology. 2014, 5 115.
Céline Martin; Patricia Passilly-Degrace; Michaël Chevrot; Déborah Ancel; Steven M Sparks; Daniel J Drucker; Philippe Besnard. Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity. Journal of Lipid Research. 2012, 53 (11), 2256-2265.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a