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3-Hydroxy-2-pyrrolidinone is used as a potent inhibitor of CDK2/cyclin A. It is also used as pharmaceutical intermediates.
Marcella Nesi; Daniela Borghi; Maria Gabriella Brasca; Francesco Fiorentini; Paolo Pevarello. A practical synthesis of the major 3-hydroxy-2-pyrrolidinone metabolite of a potent CDK2/cyclin A inhibitor. Bioorganic & Medicinal Chemistry Letters.2006, 16 3205-3208.
Hazard Statements: H302-H319
Harmful if swallowed. Causes serious eye irritation.
Precautionary Statements: P280i-P264-P305+P351+P338-P301+P312a-P337+P313-P501a
Wear eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. If eye irritation persists: Get medical advice/attention. Dispose of contents/container in accordance with local/regional/national/international regulations.