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Disuccinimidyl glutarate is used as a membrane-soluble, amine-reactive N-hydroxysuccinamide ester-based homobifunctional crosslinking reagent. It is a homobifunctionla cross-linking reagent, for ex. isolation of the insulin receptor.
Morioka, T.; Loik, N. D.; Hipolito, C. J.; Goto, Y.; Suga, H. Selection-based discovery of macrocyclic peptides for the next generation therapeutics. Curr. Opin. Chem. Biol. 2015, 26, 34-41.
Smaldone, G.; Diana, D.; Pollegioni, L.; Di Gaetano, S.; Fattorusso, R.; Pedone, E. Insight into conformational modification of alpha-synuclein in the presence of neuronal whole cells and of their isolated membranes. FEBS Lett. 2015, 589 (7), 798-804.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.