It is used as primary and secondary intermediate.
Maria F. Dalence-Guzmán.; Jörgen Toftered.; Viveca Thornqvist Oltner.; David Wensbo.; Martin H. Johansson. Synthesis of novel tetrahydroisoquinoline bronchodilators.Bioorg. Med. Chem. Lett. 2010, 20 (17),4999-5003.
Jie Wu , Yun Liao.; Zhen Yang. Synthesis of 4-Substituted Coumarins via the Palladium-Catalyzed Cross-Couplings of 4-Tosylcoumarins with Terminal Acetylenes and Organozinc Reagents.J. Org. Chem. 2001, 66 (10),3642-3645.
Hazard Statements: H225-H261-H302-H333-H314-H318-H351-H335
Highly flammable liquid and vapour. In contact with water releases flammable gas. Harmful if swallowed. May be harmful if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. Suspected of causing cancer. May cause respiratory irritation.
Precautionary Statements: P223-P210-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from any possible contact with water, because of violent reaction and possible flash fire. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.