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H59027 N-Boc-trans-4-hydroxy-L-proline methyl ester, 97%

CAS Number
74844-91-0
Synonyms

Stock No. Size Price ($) Quantity Availability
H59027-03 1g 27.50
H59027-06 5g 96.10
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N-Boc-trans-4-hydroxy-L-proline methyl ester, 97%

MDL
MFCD00076981

Chemical Properties

Formula
C11H19NO5
Formula Weight
245.28
Melting point
92-96°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in chloroform, dichloromethane and ethyl acetate.

Applications

It is used in the synthesis of For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literature References

Richard J. Freer; Alan R. Day; Natesa Muthukumaraswamy; Delia Pinon; Arthur Wu; Henry J. Showell; Elmer L. Becker. Formyl peptide chemoattractants: a model of the receptor on rabbit neutrophils. Biochemistry,1982, 21(2), 257-263.

Higgins, J., et al. N-Terminus Urea-Substituted Chemotactic Peptides:? New Potent Agonists and Antagonists toward the Neutrophil fMLF Receptor. J. Med. Chem,1996, 39(5), 1013-1015.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2933.99
TSCA
No

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