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Used in the preparation of N-[3-(3-Cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide.
Bertz SH, et al. New preparations of ethyl 3, 3-diethoxypropionate and ethoxycarbonylmalondialdehyde. Copper (I) catalyzed acetal formation from a conjugated triple bond. J. Org. Chem,1982,47(11), 2216-17.
Jagusch, C., et al. Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure. Bioorganic & Medicinal Chemistry,2008, 16(4), 1992-2010.
Hazard Statements: H227-H315-H319
Combustible liquid. Causes skin irritation. Causes serious eye irritation.
Precautionary Statements: P210-P264b-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wash face, hands and any exposed skin thoroughly after handling Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant