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It is used as a pharmaceutical intermediate.
Qingsong Liu.;Jae Won Chang.; Jinhua Wang.; Seong A. Kang.; Carson C. Thoreen.; Andrew Markhard.; Wooyoung Hur.; Jianming Zhang.; Taebo Sim.; David M. Sabatini.; Nathanael S. Gray. Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer. J. Med. Chem. 2010, 53 (19), 7146-7155.
Charles J. Paget.; Charles W. Ashbrook.; Robert Louis Stone.; Heterocyclic substituted ureas. III. Immunosuppressive and antiviral (2-pyrimidinyl)ureas. J. Med. Chem. 1969, 12 (6),1097-1098.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant