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Structural diversity in the aryl moiety (benzamides, heteroarylamides, arylimides) had a major influence on (sub)nanomolar D3 receptor affinity.
Anneke Hackling.; Robin Ghosh.;Sylvie Perachon.; André Mann.; Hans-Dieter Höltje.; Camille G. Wermuth.; Jean-Charles Schwartz.; Wolfgang Sippl.; Pierre Sokoloff.; Holger Stark. N-(ω-(4-(2-Methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as Dopamine D2 and D3 Receptor Ligands. J. Med. Chem. 2003, 46 (18),3883-3899.
Susanta K. Nayak.; M. Kishore Reddy.; Tayur N. Guru Row.; Deepak Chopra. Role of Hetero-Halogen (F···X, X = Cl, Br, and I) or Homo-Halogen (X···X, X = F, Cl, Br, and I) Interactions in Substituted Benzanilides. Cryst. Growth Des. 2011, 11 (5),1578-1596.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.