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N-Fmoc-L-alanine is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Alanine is one of the simplest amino acids - a methyl group as the side chain. This small side chain confers a high degree of flexibility when incorporated into a polypeptide chain. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group.
Roger M. Freidinger.; Jeffery S. Hinkle.; Debra S. Perlow. Synthesis of 9-fluorenylmethyloxycarbonyl-protected N-alkyl amino acids by reduction of oxazolidinones. J. Org. Chem. 1983, 48, (1), 77-81.
Shu-Li You.; Jeffery W. Kelly. Total synthesis of didmolamides A and B. Tetrahedron Letters. 2005, 46, (15), 2567-2570.
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