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5399-87-1 - 6-Chloropurine riboside, 98% - 6-Chloropurine-9-beta-D-ribofuranoside - 6-Chloro-9-(beta-D-ribofuranosyl)purine - H59634 - Alfa Aesar

H59634 6-Chloropurine riboside, 98%

CAS Number
5399-87-1
Synonyms
6-Chloropurine-9-beta-D-ribofuranoside
6-Chloro-9-(beta-D-ribofuranosyl)purine

Size Price ($) Quantity Availability
1g 90.00
5g 318.92
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6-Chloropurine riboside, 98%

MDL
MFCD00005738
EINECS
226-438-4

Chemical Properties

Formula
C10H11ClN4O4
Formula Weight
286.67
Melting point
158-162° dec.
Solubility
Soluble in water. (10.6 mg/mL)

Applications

6-Chloropurine riboside is used to study the kinetics and substrate specificity of adenosine deaminase. 6-Chloropurine riboside is benzoylated to facilitate synthesis of nucleoside derivatives such as 9-(2,3-Di-deoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine. It , especially after phosphorylation to NMP, NDP or NTP, is used as a purine substrate analogue in studies with enzymes such as Inosine monophosphate dehydrogenase (IMPDH); bacteriophage T4 RNA-ligase (EC 6.5.1.3) and pancreatic fibonuclease A.

Notes

Keep away from heat and humidity. Incompatible with strong oxidizing agents.

Literature References

Juli Alonso.; M.Victòria Nogués.; Claudi M. Cuchillo. Modification of bovine pancreatic ribonuclease A with 6-chloropurine riboside. Arch. Biochem. Biophys. 1986, 246 (2),681-689.

Michal Hocek .; Antonín Holý.; Ivan Votruba.; Hana Dvo?áková. Synthesis and Cytostatic Activity of Substituted 6-Phenylpurine Bases and Nucleosides:? Application of the Suzuki-Miyaura Cross-Coupling Reactions of 6-Chloropurine Derivatives with Phenylboronic Acids.J. Med. Chem. 2000, 43 (9),1817-1825.

Other References

Beilstein
40573
Harmonized Tariff Code
2934.99
TSCA
No

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