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N-(3,5-dichlorophenyl)benzenesulfonamide (C21) as an inhibitor of Rac activation by Dock5.
Thomas D. Penning .; John J. Talley.; Stephen R. Bertenshaw.; Jeffery S. Carter.; Paul W. Collins.; Stephen Docter.; Matthew J. Graneto.; Len F. Lee .; James W. Malecha.; Julie M. Miyashiro.; Roland S. Rogers.; D. J. Rogier .; Stella S. Yu.; Gary D. Anderson.; Earl G. Burton.; J. Nita Cogburn.; Susan A. Gregory.; Carol M. Koboldt.; William E. Perkins.; Karen Seibert.; Amy W. Veenhuizen.; Yan Y. Zhang.; Peter C. Isakson. Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:? Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib). J. Med. Chem. 1997, 40 (9),1347-1365.
German L. Perlovich.;Nadezda N. Strakhov.; Vladimir P. Kazachenko.; Tatyana V. Volkova.; Valery V. Tkachev.; Klaus-Jurgen Schaper.; Oleg A. Raevsky. Sulfonamides as a subject to study molecular interactions in crystals and solutions: Sublimation, solubility, solvation, distribution and crystal structure. Int. J. Pharm. 2008, 349 (1-2),300-313.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.