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443-48-1 - Metronidazole, 99% - 2-Methyl-5-nitroimidazole-1-ethanol - H60258 - Alfa Aesar

H60258 Metronidazole, 99%

CAS Number
443-48-1
Synonyms
2-Methyl-5-nitroimidazole-1-ethanol

Size Price ($) Quantity Availability
25g 64.27
100g 209.09
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Metronidazole, 99%

MDL
MFCD00009750
EINECS
207-136-1

Chemical Properties

Formula
C6H9N3O3
Formula Weight
171.16
Melting point
159-161°
Solubility
Soluble in water (10 mg/ml at 20°C), ethanol, methanol, chloroform, and dimethyl sulfoxide.

Applications

Metronidazole is a limited spectrum antibiotic that actively deters the growth of protozoa, anaerobic gram-positive, and anaerobic gram-negative bacteria. The first use of this antibiotic was to suppress protozoans such as Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis. It has been used to repress the growth of gram-negative anaerobes belonging to the Bacteroides and Fusobacterium, and gram-positive anaerobes such aspeptostreptococcus and Clostridia. The advantages of this antibiotic is that it affects a high percentage of gram-negative bacteria and has greater tissue penetration.

Notes

Store at 4°C.

Literature References

Paul Rutgeerts.; Martin Hiele.; Karel Geboes.; Marc Peeters.; Freddy Penninckx.; Raymond Aerts.; Raymond Kerremans. Controlled trial of metronidazole treatment for prevention of crohn's recurrence after ileal resection. Gastroenterology. 1995, 108 (6),1617-1621.

DavidG. Teasley.; MaryM. Olson.; RogerL. Gebhard.; DaleN. Gerding.; LanceR. Peterson.; MichaelJ. Schwartz.; JamesT. Lee JR. Prospective Randomised Trial Of Metronidazole Versus Vancomycin For Clostridium-Difficile-Associated Diarrhoea And Colitis.The Lancet. 1983, 322 (8358),1043-1046.

GHS Hazard and Precautionary Statements

Hazard Statements: H351-H303

Suspected of causing cancer. May be harmful if swallowed.

Precautionary Statements: P201-P281-P202-P312-P308+P313-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
611683
Harmonized Tariff Code
2933.29
TSCA
No
RTECS
NI5600000

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