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Metronidazole is a limited spectrum antibiotic that actively deters the growth of protozoa, anaerobic gram-positive, and anaerobic gram-negative bacteria. The first use of this antibiotic was to suppress protozoans such as Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis. It has been used to repress the growth of gram-negative anaerobes belonging to the Bacteroides and Fusobacterium, and gram-positive anaerobes such aspeptostreptococcus and Clostridia. The advantages of this antibiotic is that it affects a high percentage of gram-negative bacteria and has greater tissue penetration.
Paul Rutgeerts.; Martin Hiele.; Karel Geboes.; Marc Peeters.; Freddy Penninckx.; Raymond Aerts.; Raymond Kerremans. Controlled trial of metronidazole treatment for prevention of crohn's recurrence after ileal resection. Gastroenterology. 1995, 108 (6),1617-1621.
DavidG. Teasley.; MaryM. Olson.; RogerL. Gebhard.; DaleN. Gerding.; LanceR. Peterson.; MichaelJ. Schwartz.; JamesT. Lee JR. Prospective Randomised Trial Of Metronidazole Versus Vancomycin For Clostridium-Difficile-Associated Diarrhoea And Colitis.The Lancet. 1983, 322 (8358),1043-1046.
Hazard Statements: H350
May cause cancer.
Precautionary Statements: P201-P202-P281-P308+P313-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Use personal protective equipment as required. IF exposed or concerned: Get medical advice/attention. Dispose of contents/ container to an approved waste disposal plant